Imaging Beta-Adrenoceptors in the Human Brain with (5)-l'-[18F]Fluorocarazolol
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چکیده
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منابع مشابه
Imaging beta-adrenoceptors in the human brain with (S)-1'-[18F]fluorocarazolol.
UNLABELLED We evaluated the suitability of fluorocarazolol for in vivo studies of cerebral beta-adrenoceptors because (S)-1'-[18F]fluorocarazolol has a higher affinity to beta-adrenoceptors than to serotonergic receptors (pKi beta 1 9.4, beta 2 10.0, 5HT1A 7.4, 5HT1B 8.1) and rapidly crosses the blood-brain barrier. METHODS The (S)-[18F]fluorocarazolol (74 MBq, > 37 TBq/mmol) was intravenousl...
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